Umbelopsis isabellina is a potential microbe for lipid accumulation.In order to figure out the situation about lipid production utilizing Umbelopsis isabellina,the advantages of high content of polyunsaturated fatty acid (PUFA),varied strains and easy cultivation for Umbelopsis isabellina were summarized.In addition,the chemical mutation and genetic manipulation promote the strain development for even high lipid production.The optimization of cultivation process and extraction process provide a bright future of Umbelopsis isabellina in lipid production.