In biomedical fields,the 3D printing of either biomaterials or living cells is capable to construct complex 3D bio-structures,such as customized implants,engineered bone grafts,ex vivo 3D cellular aggregates and artificial organs,etc.Therefore,considering its remarkable superiorities over the individual fabrication and complex structure building,the paper affords a meaningful review of the basis technological process,application areas and developments of 3D bio-printing.The discussions based on the 3D printing of biomaterials were then presented according to current research hotspots,including the two strategies of inkjet printing and dispensing printing techniques.Its applications in manufacturing medical models,devices and implants with biomaterials were focused.In addition,tissue engineering scaffolds and three-dimensional cell aggregates fabricated via 3D bio-printing were summarized.The outlooks about the future 3D bio-printing technique were put forward.