| 徐方亮,徐影,余灯广.聚合物稀溶液环流同轴电纺制备药物零级控释纳米纤维[J].上海理工大学学报,2015,37(2):165-168. |
| 聚合物稀溶液环流同轴电纺制备药物零级控释纳米纤维 |
| Zero-Order Controlled Release Nanofibers Fabricated Using Coaxial Electrospinning with Polymer Dilute Solution as a Sheath Fluid |
| 投稿时间：2014-01-15 |
| DOI：10.13255/j.cnki.jusst.2015.02.013 |
| 中文关键词: 同轴电纺 芯鞘纳米纤维 零级控释 聚丙烯腈 鞘液 |
| 英文关键词:coaxial electrospinning core-sheath nanofibers zero-order controlled release polyacrylonitrile sheath fluid |
| 基金项目:国家自然科学基金资助项目(51373101);上海市自然科学基金资助项目(13ZR1428900);上海市教委科研创新重点资助项目(13ZZ113) |
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| 中文摘要: |
| 研究了应用聚合物稀溶液环流同轴电纺制备药物零级控释纳米纤维.以聚丙烯腈(PAN)为成纤聚合物,以阿昔洛韦为药物模型,并以2%(质量/体积)的PAN稀溶液为鞘液实施同轴电纺工艺,制备芯鞘结构载药纳米纤维.通过电镜观察,纳米纤维具有线性形貌和芯鞘结构特征;X-射线晶体衍射结果证明,阿昔洛韦以无定形态存在于PAN基材中;体外溶出实验结果表明,芯鞘纳米纤维能够消除药物初期爆释效应,调控近80%的药物零级方式释放. |
| 英文摘要: |
| The present study reports zero-order controlled release drug-loaded nanofibers fabricated using a modified coaxial electrospinning,in which a 2% (weight/volume) dilute solution of polyacrylonitrile (PAN) was exploited as a sheath fluid.With PAN and acyclovir (ACY) as the filament-forming matrix and active pharmaceutical ingredient,respectively,the prepared nanofibers are of linear morphologies and clear core-sheath structures,which were verified by electron microscopic observations.X-ray diffraction tests demonstrate that ACY presents in the PAN matrix in an amorphous status.In vitro dissolution tests show that near 80% of the contained ACY in the nanofibers is freed in a zero-order manner without initial burst effect. |
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