In recent years scientists have found that Chlorofluorocarbons (CFC) cause the ozone depletion and bring serious problems to the human environment. The CFC issue has attracted the attention of the whole world and given rise to global actionIn this paper, the historical recall in the CFC phaseout and research development in the CFC alternatives are first introduced. The Montreal Protocol and its current state of implementation are also included. The way for searching CFC alternatives and the project of CFC alternatives as well as the thermophysical properties of main alternativcs are also mentioned. Finally, the international trends and the influence on the refrigeration and air conditioning equipments as a result of CFC phaseout arc doalt with.It is hoped that this paper will promote the research work on the alternative technology of CFC in China.