Method of uniform design with restricted mixtures was used to design the experiments of powder mixtures for three dimensional printing.According to the experiments data,multi-variables nonlinear regressions were put to use,and the influencial behavior of three dimensional printing's product to the different gypsum based powder's mixtures was validated.The experimental results indicate that gypsum is the key influencial factor on the density of the products;polyvinyl alcohol can improve the product's surface quality and reduce its deformation;meanwhile,the interaction between white carbon black and polyvinyl alcohol has some influence on the density and deformation of the product.