Electrostatic spray method is used to prepare calcium alginate -sodium carboxymethyl cellulose liquid core microcapsules with high membrane intensity and good biocompatibility.The contrast experimental analyses on the spray voltage,pinhead size and other influencial factors are carried out.Then the orthogonal tests proceed to get the optimal parameters for liquid core microcapsules preparation considering membrane -formation properties under different preparation conditions.The optimal technological parameters are 10 g/L,30 g/L and 15 g/L of sodium alginate,sodium carboxymethyl cellulose and calcium chloride solutions respectively.