The distribution center location based on economics and timeliness was studied to improve the service level of logistics system.A model with time constraint was proposed to optimize the location with the target of minimizing total cost.The sequential quadratic programming (SQP),one of the solution methods to this model,was discussed.One case of distribution center location was solved by using the location model presented and the SQP.The results indicate that the location model and SQP can optimize the distribution center location with time constraint effectively.