An experimental study on an oscillating heat pipe(OHP) with the mixture of ethanol and acetone was performed.The influence factors as mix ratios and filling ratios on characteristics and thermal resistance of OHP were analyzed,and the results were compared with those in the case of the pure working medium,ethanol or acetone.The experimental results show that at low filling ratio,the capability of working medium to carry energy is weakened by acetone because of the drying-out.The thermal resistance of the mixture OHP is less than the pure one.When the filling ratio is 55%,the drying-out power of the OHP is higher than the 45%,and the thermal resistance and the speed of drying-out of the mixture OHP is less than the pure one because of the gas-liquid equilibrium.It will not dry out when the filling ratio is more than 62% but the thermal resistance of the mixture OHP is higher than the pure one because of the mass transfer resistance.The influence of mass transfer resistance is weakened with the increase of filling ratio.