When the road space is taken up to lead traffic jam, the one-way traffic organization method is usually adopted to guarantee a flexible residents' travel.In order to optimizing routes(direct and inverse routes),in the method,a multi-objective harmony search algorithm was used to deal with double target function.Its effectiveness was tested by variable synthetic diffsets and real cases.The analysis indicates the harmony search algorithm can generate more resonable solutions of balancing functions and the method has much more significant advantages compared with the current general algorithms.