The contents of calcium and phosphorus in urine,serum,and bone of mice with type 1 diabetes were investigated.The streptozotocin was injected into the mice intraperitoneally at 40 mg/kg of body weight for 5 consecutive days to induce diabetic models.The contents of calcium and phosphorus were detected by calcium and phosphorus detection kits respectively.In the mice with diabetes mellitus,serum phosphorus ascends (P<0.05),urinary phosphorus descends (P<0.05),and urinary calcium ascends (P<0.05).Calcium (P<0.05) and phosphorus (P<0.05) in femur and calcium (P<0.05) in tibia both descend.Thus,the hyperglycemia leads to the increasing loss of calcium in urine and bone,consequently induces the decrease of bone calcium content.In addition,the hyperglycemia leads to the decreased level of urinary phosphorus,and then induces the hyperphosphatemia status.