The Ni60+WC alloy cladding layer was prepared on the surface of Cu-Cr-Zr alloy by IPG-YLS-5000 fiber laser. The influence of process parameters on the dilution rate was obtained by characterizing and testing the microstructure, interfacial composition, phase composition, hardness and wear resistance of the cladding layer via SEM and XRD. The results show that raising either the laser power or laser scanning rate can promote the dilution rate. When the WC content is low, all WC particles can dissolve. When the WC content is high, there are undissolved WC particles. With the increase of WC content, the microstructure of the cladding layer become coarsened at first and then is refined, and granular phases are distributed between dendrites. The hardness and wear resistance of the cladding layer are much higher than those of matrix, and increase with the increase of WC content. The hardness of the cladding layer can be up to 1000 HV, the wear weight loss of cladding layer decreases gradually with the increase of WC content, compared with copper alloy the wear weight loss is only 1.1 g when WC content reaches 20%.