Let G be a simple graph and d_i be the degree of the vertex v_i. The Seidel Laplacian matrix of a graph G is a real symmetric matrix with diagonal elements of n-1-2d_i and off-diagonal elements of ±1. If the vertices v_i and v_j are adjacent, (S_L(G))_ij=1, and otherwise, (S_L(G))_ij=-1. The Seidel Laplacian-Estrada index was introduced and investigated. The upper and lower bounds for the Seidel Laplacian-Estrada index, and the relationship between the Seidel Laplacian-Estrada index and the Seidel Laplacian energy are provided.