In order to study the manufacturer’s coping strategy to supply interruption, the time-sensitive supply chain composed of two manufacturers and two suppliers was studied. Among them, supplier A had the risk of interruption, and manufacturer 1 could choose whether to assist supplier A, and manufacturer 2 can choose to adopt alternate supplier B and selected supplier A and chose whether to take assistance. On this basis, the decision-making model of the strategy c combination of 6 manufacturer 1 and 2 was established. The balanced solution is obtained by the game theory analysis and numerical study analysis is performed. The results show that the optimal coping strategy for the supply interruption of two manufacturers is affected by each other. While one or both of the two manufacturers take assistance measures at the same time, only when the aid strength is greater than the threshold, supply interruption can be effectively recovered. When both manufacturers choose the aid strategy, the recovery time for supply interruption is the shortest.