In infectious major public health emergencies, blockchain technology was introduced for the problem of personnel travel tracking. A blockchain-based personnel trajectory tracing system was designed to research how to reduce the difficulty of collecting, investigating and keeping the disease information due to the large number of people, complex movement trajectories, and wide range of actions. By simplifying the many subjects involved in disease prevention and control events into three parties: government agencies (regulators), corporate organizations, and ordinary users, the chain processing was then implemented. Through the development of the back-end (smart contract) and front-end (web page), a DAPP (decentralized application) with functions such as distributed recording, information data encryption, and one-click trajectory traceability was realized as well. An example was introduced into smart contract testing, and the contract content was successfully implemented, indicating that the system could effectively track the personnel in disease control.