In order to deeply understand the interaction between residual stress and constraint under fatigue, taking GH4169 superalloy as the research object, compact tension (CT) specimens with different constraints were selected. Different loads were applied to CT specimens to produce different stresses at the crack tip, and the stresses were introduced into the CT specimen as residual stress. And then, the fatigue and creep-fatigue crack propagation rates of GH4169 superalloy were systematically studied under the interaction of residual stress and constraint. The results showed that the fatigue and creep-fatigue crack propagation rates of GH4169 alloy decreased with the increase of residual compressive stress at crack tip. In contrast to the specimen with low constraint, the fatigue and creep-fatigue crack propagation rates of the specimen with high constraint were more sensitive to the change in residual stress, and it was mainly related to the Mises stress at the crack tip and the normal stress perpendicular to the crack propagation direction. Compared with the fatigue crack propagation rate, the creep-fatigue crack propagation rate was more sensitive to the change of residual stress.